Abstract
// Chen XianGuo 1 , Hao ZongYao 1 , Zhou Jun 1 , Fan Song 1 , Luo GuangYue 1 , Zhang LiGang 1 , Zhang KaiPing 1 , Zhang YangYang 1 , Liang ChaoZhao 1 1 Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, PR China Correspondence to: Liang ChaoZhao, email: liang_chaozhao@163.com Keywords: NEAT1, bladder cancer, long noncoding RNA, clinical pathologic Received: November 07, 2015 Accepted: May 28, 2016 Published: June 15, 2016 ABSTRACT Bladder cancer was the most important reason of cancer-related death around the world, and urgently requires new therapeutic methods targeting the malignant tumor. There are many reports that the long noncoding RNAs are participated in different cancers, however, limited data are found between the long noncoding RNAs and bladder cancer. Previous studies have indicated that lncRNAs play vital roles in gene regulatory processes which could influence carcinoma progression.It is well known that lncRNAs can’t code proteins, however, controlling transcription was found in the life process.In the current study,we firstly reported that NEAT1 was consistently up-regulated in bladder cancer tissues compared to the matched tissues and bladder cancer cell lines compared to the normal bladder epithelial cell and the expression level of the NEAT1 in bladder cancer tissues is closely related to its clinical pathologic grade and TNM phase. Cell proliferation inhibition, cell migration suppression and apoptosis induction were detected by knockdown NEAT1. However, it is imperative that this hypothesis is further tested through. In conclusion, NEAT1 may play oncogenic roles and can be used as a therapeutic target for treating human bladder cancer. Our finding provides a new insight into the role of the LncRNA NEAT1 in the bladder cancer.
Highlights
According to recent study, bladder cancer is still the primary reason of cancer death in the human diseases, especially in the advanced cancer patients
MiR-140, HIF-2α, miR-449b-5p/c-Met axis and MicroRNA-449a have been tested in the relation with the high expression of the NEAT1 from the previous studies
Long noncoding RNAs (LncRNAs) could have carcinogenesis and antitumor effect, which indicates that lncRNAs may be valuable biomarkers and therapeutic targets [35,36,37,38]
Summary
Bladder cancer is still the primary reason of cancer death in the human diseases, especially in the advanced cancer patients. Many bladder cancer patients are f recurred after the surgery [3] and eventual resistance to chemotherapy and radiotherapy in the subsequent treatment. This highlights the imminent requirement for discovering more molecular markers that can be potential and efficacious therapeutic targets [4]. MiR-140, HIF-2α, miR-449b-5p/c-Met axis and MicroRNA-449a have been tested in the relation with the high expression of the NEAT1 from the previous studies. There is no study the role of NEAT1 in bladder cancer. It is imperative that this hypothesis is further tested through
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