Abstract
Cell Biology Signaling through insulin-like growth factor 1 receptor (IGF-1R) promotes cancer progression, but therapies targeting IGF-1R signaling have performed poorly. Rieger et al. found that phosphorylation-dependent trafficking of IGF-1R promotes aggressive cancer cell behaviors (see the Focus by Crudden and Girnita). Ligand stimulation induced the translocation of IGF-1R to the Golgi, where it enhanced cell migration before being recycled to the plasma membrane. These findings may explain why targeting plasma membrane–localized IGF-1R has not been clinically effective. Sci. Signal. 13 , eaba3176, eabb7887 (2020).
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