Abstract
Cell Biology Signaling through insulin-like growth factor 1 receptor (IGF-1R) promotes cancer progression, but therapies targeting IGF-1R signaling have performed poorly. Rieger et al. found that phosphorylation-dependent trafficking of IGF-1R promotes aggressive cancer cell behaviors (see the Focus by Crudden and Girnita). Ligand stimulation induced the translocation of IGF-1R to the Golgi, where it enhanced cell migration before being recycled to the plasma membrane. These findings may explain why targeting plasma membrane–localized IGF-1R has not been clinically effective. Sci. Signal. 13 , eaba3176, eabb7887 (2020).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
