Abstract
Hydroxyapatite (HAp) is a major bone graft component for hard tissue regeneration. However, sintered HAp has poor formability and mechanical properties. Porous 3D scaffolds for bone tissue regeneration were printed with computer-aided modeling using poly(glycolic acid) (PGA) and HAp. PGA scaffolds containing HAp nanoparticles were fabricated with a 400μm pore size. PGA/HAp scaffolds containing 12.5wt% HAp showed considerable compressive strength, osteogenesis, mineralization, and biodegradation. In in vivo animal experiments, the PGA/HAp group exhibited 47% bone regeneration, with superior bone mineral density 8 weeks after surgery. 3D-printed PGA/HAp scaffolds could provide a feasible option to promote patient-specific bone regeneration.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.