Abstract
A question that has puzzled biologists is ‘what determines where, when and how regulatory proteins bind to the genome?’ These DNA-binding proteins control the expression of specific genes and are of fundamental importance for eukaryotic cell growth and survival. In Saccharomyces cerevisiae, repressor activator protein 1 (Rap1) is one such protein, which, together with the accessory silencing proteins Sir2, Sir3 and Sir4, functions to regulate telomere length and mating. Independent of Sir proteins, Rap1 is an essential sequence-specific transcriptional regulator of many crucial S. cerevisiae genes, acting either directly as a transcriptional activator or as an accessory for binding by other regulatory proteins. By examining the specificity of Rap1–DNA binding across the entire yeast genome, Lieb et al. 1 Lieb, J.D. et al. (2001) Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association. Nat. Genet. 10.1038/ng569 (http://www.nature.com/ng/) Google Scholar now provide some interesting answers to this fundamental biological question.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
