Abstract
Objective: Uterine leiomyoma place a significant burden on those afflicted as well as on the United States health care system. Fibroids are made up of disordered collagenous tissue and are more prevalent in African Americans compared to Caucasian Americans. Keloids are similarly made up of disordered collagenous tissue and are also more prevalent in African Americans. Despite these similarities, there is no known molecular link between these two diseases. Dermatopontin is a 22KDa extra-cellular protein that can interact with two cell signaling pathways: the integrin system and the TGF β system. Dermatopontin expression is decreased in hypertrophic scars (Kuroda et al., 1999) and in fibroids compared to myometrium using microarray analysis (Tsibris et al., 2002). It is therefore possible that differential expression of dermatopontin is a link between the fibroid and keloid phenotype.
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