Promoter region variant C-824T in the TH gene modulates the subjective effects of cocaine.

Abstract

This study examined how a promoter variant of TH (rs10770141) affects subjective effects of cocaine in 65 nontreatment-seeking individuals with cocaine dependence. Participants received cocaine/saline intravenously, and TH genotypes were evaluated. Homozygous individuals for the minor T allele reported greater "good" and "bad" subjective effects to cocaine than those with the major C allele. TH rs10770141 modulates subjective effects of cocaine in participants with cocaine dependence. These results are among the first to indicate that homozygosity of the T allele of rs10770141 modulates greater sensitivity to cocaine.