Promoter polymorphisms of NDUFA4 gene were associated with prostate enlargement of benign prostatic hyperplasia

Abstract

Benign prostatic hyperplasia (BPH) is considered the most common prostate disease in elderly men. Recent studies have suggested that specific polymorphisms might be contributed to risk factors for development of BPH. The aim of present study is to investigate whether promoter single nucleotide polymorphisms (SNPs) of the NDUFA4, mitochondrial complex associated (NDUFA4) gene are risk factors for BPH in Korean men. To evaluate the associations between promoter SNPs (rs17163801, rs17163803, rs1681288, and rs3761817) of NDUFA4 gene and clinical progress of BPH, one hundred eighty one BPH patients were recruited from Department of Urology at Kyung Hee Hospital. Prostate volume, international prostate symptom score (IPSS), and prostate specific antigen (PSA) were measured. For genetic analysis, SNPStats and SPSS 22.0 were performed. Genetic models (codominant, dominant, recessive, and log-additive models) were applied to calculate the odds ratio (OR), 95% confidence interval (CI), and P value. Among tested four SNPs, three promoter SNPs (rs17163803, rs1681288, and rs3761817) showed significant associations with prostate volume after Bonferroni’s correction (rs17163803, OR=3.00, 95% CI=1.31-6.84, Pc=0.036 in codominant 1 model; rs1681288, OR=3.53, 95% CI=1.65- 7.56, Pc=0.004 in codominant 1 model; OR=2.98, 95% CI=1.47-6.05, Pc=0.0072 in dominant model; rs3761817, OR=3.86, 95% CI=1.79-8.31, Pc=0.004 in codominant 1 model; OR=3.25, 95% CI=1.59- 6.62, Pc=0.0032 in dominant model; OR=2.19, 95% CI=1.21-3.99, Pc=0.0296). The results of present study demonstrate that specific promoter polymorphisms (rs17163803, rs1681288, and rs3761817) of the NDUFA4 gene might be associated with prostate enlargement in Korean men.