Abstract
Myelodysplastic syndrome (MDS), acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) are clonal stem cell diseases. Pathogenesis of these diseases, has not been clarified definitely. DNA methylation is the main epigenetic modification frequenly seen in humans. Inactivation of the genes that regulate cell growth, differentiation and apoptosis may play a role in cancer pathogenesis. P15(INK4B) and its functional homologue, P16(INK4A) inhibit cell cycle through cyclin‐dependent kinases 4 and 6 and regulate G1 to S transition. In this study, we examined P15(INK4B) gene promoter methylation in 13 patients with MDS and 32 patients with acute leukemia (26 AML, 6 ALL) by methylation spesific‐PCR. We have also examined its possible association with parvovirus B19 infection by PCR. P15(INK4B) methylation frequency was higher in acute leukemia patients than that of non‐malignant patients. When the patients with MDS were included, no difference was found between these groups regarding the methylation status. The possible association between P15(INK4B)methylation and parvovirus B19 infection was observed in acute leukemia patients. To our knowledge, this is the first report showing the possible association between P15(INK4B) promoter methylation and parvovirus B19 infection in adult acute leukemia. This study was supported by Mersin University BAP TF DTB AY 2004‐3.
Published Version
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