Abstract
Using bioactive and biocompatible coatings to biofunctionalized metallic implant surfaces for enhanced bone regeneration while resisting bacterial infection has attracted materials scientists' interest. Bio-metallic Ti-25Zr disc sample was prepared using powder metallurgy and then coated using an electrospinning method to form a nanocomposite fiber as a coating layer over the surface of the metal alloy substrate. Three nano-compounds (Nano-hydroxyapatite, Nano-Titanium dioxide, Nano-strontium titanite) were added individually to the Polycaprolactone/Chitosan blend to prepare the electrospinning solutions. The results show a significant improvement in biocompatibility for the coated samples after seven days of (MC3T3-E1) cell culture. Cell viability percentages were significantly higher for the coated samples compared to uncoated ones, with values of PCL/Chitosan/nHA (HA1) has 239.45±17.95%, PCL/Chitosan/nSrTiO3 (SR1) has170.09±8.12%, and PCL/Chitosan/nTiO2 (TI1) has 117.19±19.42%, while bare Ti-25Zr has 80.52±1.97%. Cell proliferation also shows a remarkable increase with time for coated samples, and the enhancement reaches 197.76% for (HA1), 111.38% (SR1), and 45.81 % (TI1) in comparison with (bare Ti-25Zr). For the antibacterial test, no inhibition zone for the control sample (bare Ti-25Zr) was observed, while the coated samples showed a suitable and comparable inhibition zone. The coating procedure is simple and inexpensive, and composite nano-fiber has high biocompatibility and promise in orthodontic and orthopedic bone regeneration.
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