Abstract
Preexposure chemoprophylaxis (PrEP) is a promising approach to HIV-1 prevention that warrants clinical evaluation, especially in regions of the world hit hardest by the epidemic. Controversy has arisen that highlights the needs of high-risk populations who frequently have limited access to information and medical care. The authors of this Policy Forum recommend involvement of community leaders and local investigators early in the development of research projects, open communication of accurate information about research, and active development of prevention and treatment infrastructure, which all serve to build the community trust that is the basis for research into finding ways to stop the spread of HIV/AIDS.
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