Abstract
Psoriasis is a common, chronic systemic inflammatory disease affecting 125 million people worldwide. It is associated with several important conditions, including psoriatic arthritis, cardiometabolic syndrome, and depression, leading to a significant reduction in patients’ quality of life. Current treatments only reduce symptoms, not cure. This review discusses the mechanisms involved in the initiation and development of the disease, the role of oxidative stress in this autoimmune disease, as well as potential therapeutic options with substances of natural origin. The main aim of the study is intended to offer a review of the literature to present plants and phytochemicals that can represent potential remedies in the fight against psoriasis. We identified many in vitro, in vivo, and clinical trials studies that evaluated the relationship between chosen natural substances and immune system response in the course of psoriasis. We sought to find articles about the efficacy of potential natural-derived drugs in controlling symptoms and their ability to maintain long-term disease inactivity without side effects, and the result of our work is a review, which highlights the effectiveness of plant-derived drugs in controlling the inflammatory burden on psoriatic patients by decreasing the oxidative stress conditions.
Highlights
Academic Editors: Halina Ekiert and Psoriasis is a chronic, autoimmunologic disease known since ancient times [1]; as the most common genetic skin disorder, it is mainly manifested by gradually magnifying and exfoliating psoriatic plates with accompanying pustules and spots [2]
The epidermis’s stratum corneum completely disappears, the granular layer disappears, T cells with glycoprotein 8 are dispersed between keratinocytes, and neutron-absorbent granulocytes accumulate in parakeratotic plates, forming Munro’s microabscesses
There are two sets of cellular responses in psoriatic changes, which disturb the balance between the activation of innate and acquired types of immune cells and the factors produced by keratinocytes, directly affecting T cells and dendritic cells (Figure 1) [1]
Summary
Academic Editors: Halina Ekiert and Psoriasis is a chronic, autoimmunologic disease known since ancient times [1]; as the most common genetic skin disorder, it is mainly manifested by gradually magnifying and exfoliating psoriatic plates with accompanying pustules and spots [2]. Dilated blood vessels extend to the highest layer of the dermis, causing bleeding after removing psoriatic plaque [3] This type of psoriasis appears as red patches of inflamed skin, raised, coated with silvery-white scales. The review presents the different in vitro, in vivo, and clinical studies with plant-derived compounds and investigates their role in the treatment of psoriatic symptoms and their immunomodulatory and anti-inflammatory effect on the immune cell populations and cytokines responsible for psoriasis development. To better understand the role of natural derived substances and present their potency in psoriasis treatment, this article comprises detailed data about the pathogenesis of this autoimmune disease in regards to inflammation process and oxidative stress, as well as the molecular interactions between natural active compounds and immune system response
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