Abstract
Traditional medicine is especially important in the treatment of neglected tropical diseases because it is the way the majority of populations of affected countries manage primary healthcare. We present a case study that can serve as an example that can be replicated by others in the same situation. It is about the validation of a local remedy for myasis in Amazonian Ecuador, which is contrasted by bibliographic chemical reviews and in silico activity tests. We look for scientific arguments to demonstrate the reason for using extracts of Lonchocarpus utilis against south American myasis (tupe). We provide a summary of the isoflavonoids, prenylated flavonoids, chalcones, and stilbenes that justify the action. We make modeling predictions on the affinity of eight chemical components and enzyme targets using Swiss Target Prediction software. We conclude that the effects of this extract can be reasonably attributed to an effect of the parasite that causes the disease, similar to the one produced by synthetic drugs used by conventional medicine (e.g., Ivermectine).
Highlights
The World Health Organization (WHO) has estimated that more than 80% of the world’s population routinely uses traditional medicine to meet their primary healthcare needs [1], and many traditional treatments involve the use of plant extracts or their active ingredients [2]
We investigate the plant known in Spanish as barbasco or poison rope, Lonchocarpus utilis A.C
Other components are The prenylated flavanols compounds found in the leaves, stems, and roots are rotenone (44%), rotenolone0 (6.7%), deguelin, prenylated flavones (3 -methoxylupinifolin), (22%), and thephrosin (4.3%) [39], which are rotenoids—isoflavones with additional pyrane/furane prenylated flavanones (2S)-6-(γ,γ-dimethylallyl)-5,40 -dihydroxy-30 -methoxy-6”, 6”-dimethylpyran rings
Summary
The World Health Organization (WHO) has estimated that more than 80% of the world’s population routinely uses traditional medicine to meet their primary healthcare needs [1], and many traditional treatments involve the use of plant extracts or their active ingredients [2]. The WHO has recognized twenty NTD: buruli ulcer, chagas disease, dengue and chikungunya, dracunculiasis (guinea-worm disease), echinococcosis, foodborne trematodiases, human african trypanosomiasis (sleeping sickness), leishmaniasis, leprosy (Hansen’s disease), lymphatic filariasis, mycetoma, chromoblastomycosis and other deep mycoses, onchocerciasis (river blindness), rabies, scabies and other ectoparasites, schistosomiasis, soil-transmitted helminthiases, snakebite envenoming, taeniasis/cysticercosis, trachoma and yaws (endemic treponematoses). These diseases represent an important cause of morbidity, disability, and mortality in the poorest people living in developing countries. This represents knowledge that can be articulated with the Western scientist [4,5]. and Plants 2020, 9, 33; doi:10.3390/plants9010033 www.mdpi.com/journal/plants
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