PROMISing New Tool Correlates Well with Kansas City Cardiomyopathy Questionnaire in Left Ventricular Assist Device Patients

Abstract

Purpose Patient-Reported Outcomes Measurement Information System (PROMIS) is a computerized assessment that has been validated across multiple disciplines and chronic disease states. There is limited use of PROMIS in the heart failure patient population. We describe PROMIS scores in a large LVAD patient cohort and compare functional domain measurement to the Kansas City Cardiomyopathy Questionnaire (KCCQ-12). Methods LVAD patients completed the PROMIS computer adaptive test for physical function, pain and depression in addition to the KCCQ-12 survey at outpatient visits. PROMIS instruments are standardized to a mean score of 50 for the general population. Only KCCQ-12 completed within 90 days of a PROMIS score were included in the analysis. The nonparametric Spearman's rank correlation measure was used to estimate the strength of the relationship between the PROMIS function score and the KCCQ-12 measure. Results From June 2017 to August 2018, 271 PROMIS scores were completed from 132 different LVAD patients (55 ± 11 years old; 81% male; 58% BTT). Time since LVAD implantation ranged from 32 days to over 8 years (median 945 days). Compared to the general population, LVAD patients reported worse functional status but similar levels of pain and depression (Figure 1). KCCQ-12 was captured for 73 different patients and demonstrated significant positive correlation between the instruments (0.713, p Conclusion The PROMIS score shows a good correlation with the KCCQ-12 in LVAD patients. Further study is needed to determine its utility in predicting outcomes.