Abstract
Kidney renal clear cell carcinoma (KIRC) is the most common malignant kidney tumor as its characterization of highly metastatic potential. Patients with KIRC are associated with poor clinical outcomes with limited treatment options. Up to date, the underlying molecular mechanisms of KIRC pathogenesis and progression are still poorly understood. Instead, particular features of Cancer-Associated Fibroblasts (CAFs) are highly associated with adverse outcomes of patients with KIRC, while the precise regulatory mechanisms at the epigenetic level of KIRC in governing CAFs remain poorly defined. Therefore, explore the correlations between epigenetic regulation and CAFs infiltration may help us better understand the molecular mechanisms behind KIRC progression, which may improve clinical outcomes and patients quality of life. In the present study, we identified a set of clinically relevant CAFs-related methylation-driven genes, NAT8, TINAG, and SLC17A1 in KIRC. Our comprehensive in silico analysis revealed that the expression levels of NAT8, TINAG, and SLC17A1 are highly associated with outcomes of patients with KIRC. Meanwhile, their methylation levels are highly correlates with the severity of KIRC. We suggest that the biomarkers might contribute to CAFs infiltration in KIRC. Taken together, our study provides a set of promising biomarkers which could predict the progression and prognosis of KIRC. Our findings could have potential prognosis and therapeutic significance in the progression of KIRC.
Highlights
The global incidence of kidney cancer is increasing
In order to explore the importance of Cancer-Associated Fibroblasts (CAFs) in Kidney renal clear cell carcinoma (KIRC), we performed a series of analyses to examine the relationship between CAFs and clinical features of KIRC
These findings suggest that increased CAFs infiltration was associated with aggressive clinical features of KIRC
Summary
The global incidence of kidney cancer is increasing. 400,000 new cases of kidney cancer are diagnosed worldwide in 2018 (Bray et al, 2018; Hoefflin et al, 2020). KIRC is the most prevalent type of kidney cancer with an increasing prevalence (Frew and Moch, 2015). KIRC is the leading cause of cancer-related death, mainly due to its highly metastatic potential and high relapse rate (Kaelin, 2009; Jemal et al, 2011; Jonasch et al, 2012). KIRC is relatively resistant to traditional chemotherapy and radiotherapy (Jonasch et al, 2012). Therapeutic options for patients with metastatic KIRC are limited, and the prognosis remains dismal
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
