Abstract
Nonpeptide defensin mimetics that act through host innate immune mechanisms are part of a novel strategy for combating drug-resistant microbes, according to Richard Scott, founder and Vice President of Research at PolyMedix of Radnor, Pa. Synthetic mimetics in this group target bacteria, fungi, and parasites with high selectivity, minimal cytotoxicity, and little risk of resistance, he says. Further, some of these mimetics are also effective against microorganisms in biofilms. He spoke during the symposium “Host Defense (Antimicrobial) Peptides: Major Players in Health and Novel Therapeutics,” during the 2012 ICAAC, held in San Francisco last September.
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