Abstract
The aim of present study was to evaluate the antidiabetic activity of the total methanolic extract (TME) and different fractions of Forsskaolea tenacissima L. aerial parts with alloxan-induced diabetic rats and estimate its wound healing activity by excision wound model in rats as well as determine its toxicological activity by lethal dose 50 % (LD50). The ethyl acetate fraction showed a significant decrease in blood glucose level (36.00 %, P < 0.001) in comparison with glibenclamide (36.14 %, P < 0.001) as standard. The TME group showed marked increase in wound healing activity (97.9 %) compared with gentamycin standard group (96.8 %). The TME is considered safe due to its LD50, which was 7 g/kg body weight.
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