Abstract
In the crystal structure of the synthetic prolyl endopeptidase (PEP) inhibitor ethyl α-oxo-1-{1-(4-phenylbutanoyl)-2(S)-indolinoyl}-2(S)-pyrrolidineacetate, C 27 H 30 -N 2 O 5 , the N-terminal amide bond is cis. The proline amide bond is trans. The dipeptide has a polyproline II conformation. The O atoms of both the ketone and the ester carbonyl groups point in the same direction.
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More From: Acta Crystallographica Section C Crystal Structure Communications
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