Abstract
P rolotherapy is recognized as one of the most popular complementary and alternative medical therapies to treat chronic musculoskeletal and arthritic pain. This therapeutic approach has been in clinical practice for more than 100 years to treat various chronic conditions under different names. Dr. George Hackett formalized the therapy in the 1950s as a viable therapeutic strategy to treat ligamentous laxity and related musculoskeletal conditions. Briefly, prolotherapy is an injection therapy consisting of repeated injections of an irritant solution at or near the site of connective tissue dysfunction over the course of several months. Even though several clinical and preclinical studies demonstrated the potential of the therapeutic approach, the mechanism of action of the injection therapy is not fully known. It was known previously by the name sclerotherapy based on the observation that the injected solution was sclerosing the connective tissue. This property has shown to stabilize joints by tightening interarticular ligaments and joint capsule
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