Abstract
To investigate the genetic mechanisms involved in morphological transformation of Syrian hamster embryo (SHE) cells, we have studied the transforming potential of 3-aminobenzamide (3-AB). It was found that prolonged exposure to 3-AB induced morphological transformation of SHE cells as well as C3H10T 1/2 cells. At similar doses, 3-AB induced SCEs and chromosomal alterations (gaps, breaks and exchanges) in SHE cells, but no mutations at the hypoxanthine-guanine phosphoribosyl transferase locus. These data strongly suggest morphological transformation can result from genetic alterations other than gene mutations. The possible nature of these genetic alterations involved will be discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
