Abstract
Investigators at Tel-Aviv Sourasky Medical Center, and three other medical centers in Israel, obtained data, prospectively, on all children presenting in the emergency departments from January 2008 to March 2010 with prolonged febrile seizures.
Highlights
Using modified adult guidelines (Zuliani L, et al J Neurol Neurosurg Psychiatry 2012 Jun;83(6):638-45), patients were classified as having definite autoimmune epilepsy in 5, probable in 1, possible in 3, unlikely in 2, and unknown in 2 patients, according to the neuronal surface or GAD antibodies, and response to immune therapy
Classical NMDAR encephalitis was diagnosed in 3 patients, VGKC in 2, limbic encephalitis with negative antibodies in 2, epilepsy with other autoimmune diseases in 3 (1 with GAD antibodies), fever-induced refractory epileptic encephalopathy in school-aged children (FIRES) in 2, and epileptic encephalopathy associated with VGKC antibodies in 1
Seven with suspected autoimmune epilepsy were positive for neuronal surface antibodies (NMDAR, VGKC-complex, and GAD)
Summary
Using modified adult guidelines (Zuliani L, et al J Neurol Neurosurg Psychiatry 2012 Jun;83(6):638-45), patients were classified as having definite autoimmune epilepsy in 5, probable in 1, possible in 3, unlikely in 2, and unknown in 2 patients, according to the neuronal surface or GAD antibodies, and response to immune therapy. Classical NMDAR encephalitis was diagnosed in 3 patients, VGKC in 2, limbic encephalitis with negative antibodies in 2, epilepsy with other autoimmune diseases in 3 (1 with GAD antibodies), fever-induced refractory epileptic encephalopathy in school-aged children (FIRES) in 2, and epileptic encephalopathy associated with VGKC antibodies in 1.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
