Abstract
increased viral load by 0.42 log (95% CI 0.29-0.78, p = 0.0002), higher than that reported in adults. These patients’ viral loads returned to levels similar to those at baseline after treatment. In 13 patients with high parasitaemia (10-20/HPF), the mean increase in viral load was 0.53 log (0.14 to 0.51), p < 0.0001, remaining significantly higher than at baseline after treatment ie. mean difference (signed-rank test) in viral load “before” and “after” malaria was significant. Discussion P. falciparum malaria increased HIV-1 viral loads in children, with some viral loads remaining elevated several weeks after antimalarial treatment. Prolonged posttreatment elevation has important implications for the clinical course and the potential for transmission in sexually active adults.
Highlights
Malaria and HIV-1 infection cause significant morbidity and mortality in children in sub-Saharan Africa
The effect of malaria on viral loads in Children living with AIDS (CLWA) is not clearly known
They were monitored for development of P. falciparum malaria, which was treated with CQ+SP and the children followed up for 28 days
Summary
Introduction Malaria and HIV-1 infection cause significant morbidity and mortality in children in sub-Saharan Africa. Recurrent malaria infection increases HIV-1 viral load in adults and increases the rate of progression of HIV-1 infection to AIDS. The effect of malaria on viral loads in Children living with AIDS (CLWA) is not clearly known
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