Abstract
In acute experiments on cats injection of tetanus toxin, which disturbs various types of inhibition, into the orbital cortex caused the formation of a local generator of pathologically enhanced excitation in that region. In chronic experiments on cats with such a generator in the orbital cortex pathological changes of sleep appeared: a decrease in the duration of wakefulness and the development of a prolonged sleep state, while the normal ratio between slow-wave and paradoxical stages in the sleep continuum was preserved. The results confirm the view that the orbitofrontal cortex participates in the induction of sleep and they develop the general concept of the role of determinant structures in the activity of the nervous system and the theory of generator mechanisms of neuropathological syndromes characterized by hyperactivity of its systems.
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