Abstract
Hexobarbital sleeping time (HST) and zoxazolamine paralysis time (ZPT) were measured in male mice after oral administration of 14 food additives. HST and ZPT were significantly (P<0.05) prolonged when hexobarbital or zoxazolamine was given intraperitoneally after pretreatment with diphenyl, o-phenylphenol, piperonyl butoxide or thiabendazole. One hour after the pretreatment, the maximum prolongation of HST and ZPT was observed.To prolong HST or ZPT in mice, it was necessary to administer 50mg/kg of diphenyl, o-phenylphenol or thiabendazole to them. However, a dose of only 5mg/kg of piperonyl butoxide prolonged HST and ZPT.
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