Abstract
Proline dehydrogenase (PRODH) gene polymorphisms and the risk of schizophrenia in Iranian populations
Highlights
Schizophrenia is a highly heritable mental disorder which can be occurred as a result of mutations or single nucleotide polymorphisms (SNPs) in various genes
Our findings showed that G1496A and C1482T polymorphisms in patients were significantly higher than controls and there were meaningful correlations between the occurrence of these polymorphisms and schizophrenia in the population (p < 0.001)
We evaluated for the first time whether three polymorphisms G1496A, G758A and C1482T in Proline dehydrogenase (PRODH) gene are related to increased risk of schizophrenia in the Iranian population
Summary
Schizophrenia is a highly heritable mental disorder which can be occurred as a result of mutations or single nucleotide polymorphisms (SNPs) in various genes. Proline dehydrogenase (PRODH) gene is one of the most important genes which can be associated with increased risk of schizophrenia in several populations. We considered the effect of PRODH gene polymorphisms on the incidence of schizophrenia in Iranian populations.
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