Abstract
Proliferative verrucous leukoplakia (PVL) is an aggressive form of oral leukoplakia that has a high morbidity and is more common in a woman with no smoking habit. A 68-year-old Caucasian male patient presented with a history of use of a removable dental prosthesis and reported to be a heavy smoker for the last 53 years, with a recent interruption of alcohol and other drug abuse. Clinical examination revealed a widespread leukoplakia lesion with 4 major intra-oral sites at the upper superior alveolar ridge and palate. Two sites were characterized as a homogeneous plaque, and 2 presented an exophytic verrucous surface. The first biopsy revealed hyperkeratosis and papillomatosis. The patient was referred to laser surgery treatment. Histologic findings revealed hyperkeratosis and papillomatosis, but now 1 of the sites revealed mild dysplasia. The final diagnosis was PVL, and the patient is still in follow-up, with no signs of new lesions 3 months after surgical intervention.
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