Abstract
We investigated morphological changes of the arterial system in the kidneys under prolonged, continuous-flow left heart bypass. After 2 weeks of pulsatile left heart bypass in 12 goats, continuous-flow left heart bypass was conducted for the next 4 weeks. After autopsy, the kidneys were subjected to pathological evaluation. The media of the afferent arterioles were frequently thickened by increased quantities of mature smooth muscle cells (SMC). The juxtaglomerular areas (JGA) were expanded due to increases in the number and size of SMCs and/or SMC-like cells. We speculate that prolonged continuous-flow left heart bypass causes SMCs and/or SMC-like cells to proliferate in the media and perivascular tissue of the afferent arterioles.
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