Abstract
Proliferative Activity of Healthy and Degenerated Intervertebral Disc Cells in vitro under Bone Morphogenetic Proteins’ Influence: Implications for Cell Therapy
Highlights
Degeneration of the intervertebral disc (IVD) is a complex process, which includes changes in IVD nutrition, decreased cell viability and cellularity, quantitative and qualitative changes in the extracellular matrix and the disc biomechanics [1]
Cells of degenerated IVD were isolated from tissue biopsies of annulus fibrosus (AF) and nucleus pulposus (NP) taken from patients undergoing a normal discectomy or fusion procedure on the lumbar spine
We found that bone morphogenetic proteins (BMP)-2, 7, and 14 had no significant effect on the proliferation of healthy cells from NP, yet slightly increasing the proliferation of degenerated NP and AF cells
Summary
Degeneration of the intervertebral disc (IVD) is a complex process, which includes changes in IVD nutrition, decreased cell viability and cellularity, quantitative and qualitative changes in the extracellular matrix and the disc biomechanics [1]. It remains, unclear which of these processes are. The IVD degeneration is, for a great part, a genetically determined process [2, 3]. The complexity of the involved pathophysiological mechanisms makes it difficult to search for potential therapeutic targets and to rationalize the means of biological correction
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