Abstract
Myeloid metaplasia in liver, spleen, adrenal, and other organs, as well as myeloid white cell hyperplasia of the bone marrow, was produced in 33 guinea pigs by injections with extracts of urines obtained from patients with chronic myeloid leucemia. One animal, similarly treated, showed no change. Twenty-eight guinea pigs, injected with extracts of the urine from normal individuals and individuals with diseases other than myeloid leucemia, showed no myeloid change. The animals which received the extracts of urine from patients with chronic lymphoid leucemia and multiple myeloma showed lymphoid hyperplasia. Two animals showed hyperplasia which has not been classified.
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