Abstract
The effect of high doses of omeprazole on the proliferation of the histamine-storing endocrine cells in the oxyntic mucosa, the so-called enterochromaffinlike (ECL) cells, was studied in the rat stomach by combining immunocytochemical staining for histamine with autoradiography after in vivo labeling with [3H]thymidine. Under basal conditions the ECL cells divided very slowly. A progressive increase in the ECL cell labeling index was observed from the second day of omeprazole treatment. The ECL cell density increased progressively from the ninth day of treatment. The plasma gastrin levels were doubled and the labeling index of the cells in the progenitor cell zone was significantly increased. Our data indicate that the omeprazole-evoked ECL cell hyperplasia is a result of accelerated self-replication. The positive correlation between the plasma gastrin concentration and the ECL cell labeling index is compatible with a causal relationship between circulating gastrin levels and increased ECL cell density.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
