Abstract
In experiments with Polyoma-virus-induced autochthonous fibrosarcomas of the rat kidney, the cell cycle parameters, the proliferative fraction, and the rate of cell loss were determined as essential factors for tumor growth. The results demonstrate a mean cell cycle time of 21·1 hr ± 12·8 by the 10th day, 26·3 hr ± 20·9 by the 20th day, and 29·8 hr ± 15·4 by the 30th day of growth. The proliferative fraction was between 39 and 50% and remained constant during the course of tumor growth. The critical factor in the great decrease in tumor growth rate was the rate of cell loss which, in large tumors, was up to about 100% of the rate of cell production. These results differ only from those obtained in most solid transplanted or spontaneous neoplasms with regard to the constancy of the proliferative fraction.
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