Abstract

PROLACTIN and thyrotropin (TSH) are protein hormones that appear to be produced by different cell populations of the anterior pituitary gland.1 TSH secretion is stimulated by thyrotropin-releasing hormone (TRH), a releasing factor from the hypothalamus whose effects have been well studied in man.2 Prolactin secretion, on the other hand, appears to be under tonic inhibition by a hypothalamic inhibitory factor,1 but studies in animals have suggested an additional hypothalamic stimulating factor as well.3 4 5 Recently, it has been shown in tissue culture6 and intact man7 , 8 that TRH promotes pituitary prolactin secretion in a manner qualitatively and quantitatively similar to its stimulation . . .

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