Abstract
BackgroundOur study aimed to investigate if serum prolactin (PRL) levels associated with insulin resistance and beta-cell dysfunction in infertile patients with polycystic ovary syndrome (PCOS).MethodsThis was a retrospective cross-sectional study performed in the reproductive medicine center of the first affiliated hospital of Wenzhou Medical University. From January 2007 to August 2018, a total of 792 PCOS and 700 non-PCOS infertile women were included. All patients’ prolactin levels were in the normal range. PCOS was diagnosed according to the Rotterdam Criteria. Anthropometric parameters, blood pressure, serum prolactin levels, sex hormones, fasting lipids, fasting plasma glucose (FPG), fasting insulin (FINS) and hepatic biological parameters were measured in all subjects.ResultsSerum prolactin levels in PCOS women were significantly decreased compared with levels in non-PCOS women after adjusting for age and BMI (P < 0.05). Moreover, we found that prolactin levels were positively associated with high-density lipoprotein cholesterol (HDL-C) and negatively associated with age, BMI, waist circumference (WC), hip circumference (HC), luteinizing hormone/follicle stimulating hormone (LH/FSH), estradiol (E2), FINS, homeostasis model assessment of insulin resistance (HOMA-IR), homeostasis model assessment of β (HOMA-β), triglyceride (TG) and alanine aminotransferase (ALT) (P < 0.05). After adjusting for age and BMI, multiple linear regression analysis revealed that LH, LH/FSH, E2, FINS, HOMA-IR, and HOMA-β were negatively associated with serum PRL (P < 0.05).ConclusionsLow serum PRL levels within the normal range associates with a higher incidence of insulin resistance and beta-cell dysfunction in infertile women with PCOS.
Highlights
Our study aimed to investigate if serum prolactin (PRL) levels associated with insulin resistance and beta-cell dysfunction in infertile patients with polycystic ovary syndrome (PCOS)
We found that prolactin levels were positively associated with high-density lipoprotein cholesterol (HDL-C) and negatively associated with age, BMI, waist circumference (WC), hip circumference (HC), luteinizing hormone/follicle stimulating hormone (LH/ Follicle stimulating hormone (FSH)), estradiol (E2), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMAIR), homeostasis model assessment of b (HOMA-b), triglyceride (TG) and alanine aminotransferase (ALT) (P < 0.05)
After adjusting for age and BMI, multiple linear regression analysis revealed that LH, LH/FSH, E2, FINS, Homeostasis model assessment of insulin resistance (HOMA-IR), and HOMA-b were negatively associated with serum PRL (P < 0.05)
Summary
Our study aimed to investigate if serum prolactin (PRL) levels associated with insulin resistance and beta-cell dysfunction in infertile patients with polycystic ovary syndrome (PCOS). It is reported that the role of PRL on glucose metabolism and insulin resistance depends on its circulating concentration. Increasing evidence links low PRL levels within the normal range with markers and outcomes of metabolic dysfunction [19,20,21]. Previous studies have shown that serum PRL levels were negatively correlated with insulin sensitivity and glucose in young individuals [22]. The maintenance of high serum PRL levels within the physiological range can improve insulin sensitivity and promote the proper distribution of fat, which modifies the metabolic dysfunction [20]
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