Abstract
Summary Specific estradiol binding (SEB) in uterine and breast tissues was measured by tissue incorporation of 3 H-estradiol in the presence and in the absence of an estrogen competitor, nafoxidine hydrochloride. SEB in explants from uterus during pregnancy was much lower than that during lactation or from uterus of young rats. The presence of prolactin (5 μg/ml) in organ culture increases SEB capacity in these estrogen target tissues, and progesterone (1 μg/ml) appears to offset this prolactin-induced increase of SEB. These results represent the first in vitro demonstration of prolactin regulation on estradiol binding in estrogen target tissues. The possible mechanisms of interaction among these hormones are discussed.
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