Abstract
The effect of treatment with prolactin or bromocryptine on testicular steroidogenesis and serum hormone levels were studied in immature and mature bonnet monkeys. Leydig cells alone showed the presence of 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) and 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) in normal immature and mature monkeys. Administration of prolactin increased the activity of 3 beta-HSD and 17 beta-HSD in Leydig cells from mature monkeys, and also increased the serum levels of testosterone. Bromocryptine treatment induced exactly the opposite effect. These changes occurred in the absence of any change in serum gonadotrophin levels. In immature monkeys, prolactin and bromocryptine had no significant effect. These results suggest a direct stimulatory effect of prolactin on testicular steroidogenesis in mature monkeys.
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