Projections of the superior cerebellar peduncle in rats and the development of new connections in response to neonatal hemicerebellectomy.

Abstract

The normal distribution pattern of cerebellar efferents was determined using the Fink-Heimer technique in adult rats that sustained stereotaxic transection of the superior cerebellar peduncle. This pattern was found to be essentially similar to earlier studies and corroborated more recent reports of projections to the pontine gray and inferior olivary nuclei. Comparisons were made to a second group of animals that underwent neonatal hemicerebellectomy in addition to adult transection of the contralateral superior cerebellar peduncle. Abnormal projections to the ipsilateral red nucleus and ventral thalamus were observed in addition to evidence suggestive of axonal sprouting within the oculomotor complex. These animals also demonstrated an absence of cells in the pontine gray and inferior olive on the side contralateral to the hemicerebellectomy and in the lateral reticular and lateral cuneate nuclei on the ipsilateral side.