Projections from the nucleus of the basal optic root and nucleus lentiformis mesencephali to the inferior olive in pigeons (Columba livia)

Abstract

The nucleus of the basal optic root (nBOR) of the accessory optic system (AOS) and the pretectal nucleus lentiformis mesencephali (LM) are involved in the analysis of optic flow and the generation of the optokinetic response. Previous studies have shown that the nBOR projects bilaterally to the medial column (mc) of the inferior olive (IO) and the LM projects to the ipsilateral mc. In the present study the retrograde tracer cholera toxin subunit B was injected into either the caudal or rostral mc. From all injections, retrogradely labeled cells were seen in the ipsilateral pretectum along the border of the medial and lateral subnuclei of the LM. Cells were also seen in bilaterally in the nBOR. On the contralateral side, a discrete group of cells was labeled in the rostral margin of the nBOR. These cells were localized in the dorsal portion of the nBOR proper and some were found in the adjacent nBOR dorsalis. On the ipsilateral side, a diffuse group of cells was seen in the caudal nBOR. Most of these cells were in the nBOR dorsalis and outside the nBOR complex in the area ventralis of Tsai and the reticular formation. From the injections into the caudal mc, a greater proportion of labeled cells was found in the LM, whereas a greater proportion of cells was found in the nBOR from the injections into the rostral mc. This differential projection from LM and nBOR to the caudal and rostral mc is consistent with the optic flow preferences of neurons in the mc, and a similar pattern of connectivity has been found in mammalian species.