Projecting the impact of variable MDR-TB transmission efficiency on long-term epidemic trends in South Africa and Vietnam

Phillip P Salvatore,David W Dowdy,Emily A Kendall,George H Durham,Dena Seabrook,Jessie Brown

doi:10.1038/s41598-019-54561-9

Phillip P Salvatore, David W Dowdy + Show 4 more

Open Access

https://doi.org/10.1038/s41598-019-54561-9

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Abstract

Whether multidrug-resistant tuberculosis (MDR-TB) is less transmissible than drug-susceptible (DS-)TB on a population level is uncertain. Even in the absence of a genetic fitness cost, the transmission potential of individuals with MDR-TB may vary by infectiousness, frequency of contact, or duration of disease. We used a compartmental model to project the progression of MDR-TB epidemics in South Africa and Vietnam under alternative assumptions about the relative transmission efficiency of MDR-TB. Specifically, we considered three scenarios: consistently lower transmission efficiency for MDR-TB than for DS-TB; equal transmission efficiency; and an initial deficit in the transmission efficiency of MDR-TB that closes over time. We calibrated these scenarios with data from drug resistance surveys and projected epidemic trends to 2040. The incidence of MDR-TB was projected to expand in most scenarios, but the degree of expansion depended greatly on the future transmission efficiency of MDR-TB. For example, by 2040, we projected absolute MDR-TB incidence to account for 5% (IQR: 4–9%) of incident TB in South Africa and 14% (IQR: 9–26%) in Vietnam assuming consistently lower MDR-TB transmission efficiency, versus 15% (IQR: 8–27%)and 41% (IQR: 23–62%), respectively, assuming shrinking transmission efficiency deficits. Given future uncertainty, specific responses to halt MDR-TB transmission should be prioritized.

Highlights

The global epidemic of multidrug resistant tuberculosis (MDR-TB) represents a major challenge to worldwide TB control efforts
This analysis illustrates that the future trajectories of multidrug-resistant tuberculosis (MDR-TB) in South Africa and Vietnam are highly dependent on the transmission efficiency of MDR-TB and its trend over time
If the transmission efficiency of MDR-TB increases over time, the incidence of MDR-TB could rise as high as 72 per 100,00 in South Africa and 70 per 100,000 in Vietnam. These findings underscore the importance of additional research to better estimate the relative transmission efficiency of MDR-TB from an epidemiological perspective, including evaluation of multiple settings and trends over time

Summary

Introduction

The global epidemic of multidrug resistant tuberculosis (MDR-TB) represents a major challenge to worldwide TB control efforts. If MDR-TB fails to transmit efficiently, improved DS-TB management alone could be sufficient to contain epidemics of MDR-TB, but if MDR-TB transmits nearly or as efficiently, it may replace DS-TB as the dominant TB strain[2] Predicting these epidemic trajectories remains a challenge. We used a mathematical model of DS-TB and MDR-TB to project future trajectories of MDR-TB epidemics in South Africa and Vietnam under three competing assumptions about the relative transmission efficiency of MDR-TB. Within this framework, we first explore the relative ability of models using these different assumptions to recapitulate empirical DS-TB and MDR-TB incidence data. We show that models using these assumptions forecast highly divergent epidemic trajectories of MDR-TB

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