Abstract
The incidence of oropharyngeal cancer (OPC) is rapidly increasing. This study aimed to describe the temporal trends and projection of OPC incidence. Incidence data were obtained from the Surveillance, Epidemiology, and End Results (SEER) database and trends were calculated using the joinpoint regression model. The incidence of OPC in the US population significantly increased by 1.94% (95% confidence interval [CI], 1.65%-2.23%) per year from 2000 to 2015. OPC was projected to increase continuously over the next 30 years, with more than half of projected new OPC cases being found in non-Hispanic white men aged 55-69 years. By 2045, OPC will become the third most common cancer in 55-69-year-old non-Hispanic white men in the United States. The incidence of OPC is expected to increase substantially in the US population, particularly among middle-aged non-Hispanic white men. Our projections may have implications for policy makers.
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