Abstract
As one of the most important cortical structures in the brain, the visual cortex plays a primary role in processing visual data. Observing the metabolic changes in this region using single-voxel MR spectroscopy (MRS) can provide a plethora of information on the disease stage and progress in vivo. For single-voxel MRS experiments, a target voxel is always chosen and specifically investigated. The volume of the voxel must be sufficiently small to avoid any interference from adjacent areas but large enough to maximise its signal-to-noise ratio (SNR). Of the factors used to improve SNR, e.g. enlarging voxel size or increasing the number of signal averaging, the optimisation of the RF coil can contribute significantly to the SNR improvement. In this work, we compared and optimised RF coils which include a circularly-polarised (CP) high-pass birdcage coil and two CP surface coils with different dimensions. The coils were particularly designed for the entire rat head, brain and the target region (visual cortex), respectively. The performance of these coils was evaluated based on the project-specific purpose of investigating metabolite concentration changes in the visual cortex of the in vivo rat brain, assessed by means of single-voxel MRS at 9.4 T. In the SNR comparison, the values obtained using the optimised small loop coil were found to be approximately 5 and 1.35 times higher than those using the birdcage volume head coil and the medium-sized loop coil, respectively. In other words, using the optimised coil rather than, for example, the birdcage coil allows the acquisition to be completed more quickly by a factor of 25 times. In conclusion, by using the optimised setup, we can i) benefit either from reduced measurement time or in the acquisition of high-quality MR images or ii) obtain spectra with a minimum quantification error.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.