Abstract
Objective: To study and analyze serum levels of interleukins (IL): IL-1β, IL-2 and IL-6 in patients with myocardial infarction and chronic obstructive pulmonary disease.Materials and methods: In 85 people were examined: 28 patients with myocardial infarction, 37 patients with comorbid pathology (myocardial infarction and chronic obstructive pulmonary disease) and 20 somatically healthy volunteers as a control group. Determination of IL-1β, IL-2 and IL-6 levels was basing on enzyme immunoassay.Results: The median and inter-percentile range of IL-1β, IL-2 and IL-6 in the donors did not differ significantly from the data of the manufacturer. In the group of patients with myocardial infarction and in patients with comorbid pathology a statistically significant increase in the level of median and inter-percentile range of cytokines was revealing compared with the control group. The highest levels of IL-1β, IL-2 and IL-6 were detecting in the group of patients with comorbid pathology. IL-6 was found to be an independent marker of increased risk of STEMI and an increase in its concentration later than 12 hours after hospitalization is associated with the risk of future cardiovascular death or new myocardial infarction.Conclusion: Analysis of the dynamics of the level of IL-1β, IL-2 and IL-6 has a high prognostic value in patients with myocardial infarction and in patients with comorbid pathology.
Highlights
Proinflammatory cytokines in patients with acute myocardial infarction against the background of chronic obstructive pulmonary disease
In the group of patients with myocardial infarction and in patients with comorbid pathology a statistically significant increase in the level of median and inter-percentile range of cytokines was revealing compared with the control group
The highest levels of IL-1β, IL-2 and IL-6 were detecting in the group of patients with comorbid pathology
Summary
Цель: изучить и проанализировать сывороточный уровень интерлейкинов (ИЛ) ИЛ-1β, ИЛ-2 и ИЛ-6 у больных с острым инфарктом миокарда на фоне хронической обструктивной болезни легких. Материалы и методы: всего обследовано 85 человек: 28 больных инфарктом миокарда, 37 больных коморбидной патологией (инфаркт миокарда на фоне хронической обструктивной болезни легких) и 20 соматически здоровых добровольца в качестве группы контроля. Результаты: в группе больных инфарктом миокарда и у больных коморбидной патологией выявлено статистически значимое повышение уровня изучаемых цитокинов по сравнению с группой контроля. Самые высокие уровни ИЛ-1β, ИЛ-2 и ИЛ-6 определялись в группе больных с коморбидной патологией. Заключение: анализ динамики уровня ИЛ-1β, ИЛ-2 и ИЛ-6 обладает высокой прогностической значимостью как у больных с инфарктом миокарда, так и у больных с коморбидной патологией. Провоспалительные цитокины у больных с острым инфарктом миокарда на фоне хронической обструктивной болезни легких.
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