Abstract
The aim of this study was to investigate the differential time-course responses of the auditory cortex to repeated auditory stimuli in children with autism spectrum disorder (ASD) showing auditory hypersensitivity. Auditory-evoked field values were obtained from 21 boys with ASD (12 with and 9 without auditory hypersensitivity) and 15 age-matched typically developing controls. M50 dipole moments were significantly increased during the time-course study only in the ASD with auditory hypersensitivity compared with those for the other two groups. The boys having ASD with auditory hypersensitivity also showed more prolonged response duration than those in the other two groups. The response duration was significantly related to the severity of auditory hypersensitivity. We propose that auditory hypersensitivity is associated with decreased inhibitory processing, possibly resulting from an abnormal sensory gating system or dysfunction of inhibitory interneurons.
Highlights
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by qualitative impairments in social interaction and communication, as well as by restricted behavior and interests [1]
We recently reported that auditory hypersensitivity in ASD is strongly correlated with delayed M50/ M100 peak latencies as well as with increased M50 dipole moments [4]
The scores of full intelligence quotient showed no difference between ASD groups with and without auditory hypersensitivity [F (1, 19) = 0.057, p = 0.814, g2 = .02]
Summary
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by qualitative impairments in social interaction and communication, as well as by restricted behavior and interests [1]. Unusual perceptual abilities are common in ASD; for example, many individuals with ASD express extreme reactions to at least one sensory modality, such as auditory stimulation [3]. These individuals perceive innocuous sounds as painful and frightening noise; and in some cases, those sounds may be perceived as phobic stimuli and result in radical behavioral responses in autism spectrum individuals. M50/M100 peak responses are activated by auditory stimuli, which responses reflect the process of sensory input and originate in or near the primary auditory cortex [5] We concluded that these phenomena possibly resulted from neurological immaturity or functional abnormalities in the primary auditory cortex
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