Abstract
INTRODUCTION Progressive transformation of germinal centers (PTGC) was first described by Lennert and Muller-Hermelink in 1975 as enlargement of secondary follicles with blurring of the germinal center-mantle zone junction [1-3]. PTGC is a clinically asymptomatic condition characterized by persistent lymphadenopathy. PTGC is more common in males compared to females, with an approximate 3:1 ratio [4]. The etiology of PTGC is unknown, but is proposed to be a result of abnormal follicle hyperplasia following antigenic stimulation [1]. PTGC has been proposed to be part of a sequential spectrum of hyperplastic follicles, follicular lysis, and PTGC, with progressive ingression of mantle B cells [5]. The germinal center architecture consisting of centroblasts, centrocytes, plasma cells, and dendritic retinacular cells are largely replaced with small lymphocytes [1-3].
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