Abstract
The study investigated how renal sympathetic nerve activity was involved in the development of cold‐induced hypertension in rats. Male Wistar rats were chronically instrumented to allow recording of renal (RSNA), lumbar (LSNA) sympathetic nerve activity, measurement of systemic arterial pressure and infusion of vasoactive drugs. At least three days after the surgery, rats were placed in an environmental temperature of 10 °C for 96 hours. The cold exposure caused an immediate increase in arterial pressure from 103 }2 to 118 }1 mmHg (P<0.05) associated with simultaneous increases in RSNA, of 55%, LSNA, of 211% and heart rate, of 86beats/min (all P<0.05). Subsequently, RSNA increased further in a progressive manner reaching 152% at the end of the cold exposure while LSNA and heart rate remained at the initial increased levels. These data suggest that cold exposure activates RSNA in a cumulative manner, which may contribute to the development of cold‐induced hypertension in rats. JSPS Grant.
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