Abstract
We present the longitudinal neurolinguistic, neuropsychological and neurologic follow-up of a 64 y.o. right-handed woman, who developed progressive apraxia of speech (PAOS), followed by peripheral agraphia then a left corticobasal syndrome (CBS). Neuroimaging (CT, MRI and FDG-PET) unequivocally showed progressive right hemispheric atrophy and hypometabolism. This particular evolution first confirms that PAOS is a phenotype of probable corticobasal degeneration (CBD). More importantly, this case underpins the neural organisation of motor planning processing in relation with speech, as well as graphic and limb praxis impairments, and constitutes a rare example of crossed-PAOS.
Highlights
We present the longitudinal neurolinguistic, neuropsychological and neurologic follow-up of a 64 y.o. right-handed woman, who developed progressive apraxia of speech (PAOS), followed by peripheral agraphia a left corticobasal syndrome (CBS)
Apraxia of speech (AOS) is a complex motor speech disorder which has been attributed to impaired planning/programming of gestural scores for articulation [1, 2]
Neuropsychological and extensive neurological examination at the age of 72 years old indicated an unmistakable CBS of the left upper limb characterized by ideomotor apraxia, severe rigidity, bradykinesia, postural tremor, myoclonus, left-sided extinction on bilateral stimulation and alien hand sign
Summary
We present the longitudinal neurolinguistic, neuropsychological and neurologic follow-up of a 64 y.o. right-handed woman, who developed progressive apraxia of speech (PAOS), followed by peripheral agraphia a left corticobasal syndrome (CBS).
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