Abstract

Method Thirty-one first-episode patients with schizophrenia were included in this longitudinal study. MRI brain scans were obtained at inclusion (T0) and after 1-year (T1). Intracranial, total brain, cerebral gray and white matter, cerebellar, lateral and third ventricle volumes were measured. After a follow-up period of 5.3 (SD = 0.8) years global outcome was measured with the Camberwell Assessment of Need (CAN) and clinical outcome was measured with the Positive and Negative Syndrome Scale (PANSS). To examine associations between early progressive brain volume changes (T1 minus T0) and five-year outcome Pearson product-moment correlations were performed with intracranial volume and age as covariates.

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