Progression of Thyrotropinemia in Overweight and Obese Children From Puducherry, India

Abstract

To assess the progression of thyrotropinemia to overt hypothyroidism in overweight and obese children. 150 overweight and obese children aged 5-15 years were enrolled. Free T4 and thyroid stimulating hormone (TSH) were done at enrollment and for those with TSH >5 mIU/L, TSH levels were repeated after 1 year. The mean (SD) body mass index (BMI) and TSH were 23.8 (3.19) kg/m2 and 2.70 (2.44) mIU/L, respectively. 17 children had thyrotropinemia (TSH between 10-15mIU/L); 10 (84.6%) of these children attained normal TSH levels at one year follow-up, and none progressed to overt hypothyroidism (TSH >15 mlU/L). Levels of 5-15 mIU/L are common in asymptomatic overweight and obese children. Majority of these children revert back to normal TSH levels on follow-up.