Progression of Focal Nodular Hyperplasia in a 43-Year-Old Woman with Breast Cancer

Abstract

Most liver masses that are incidentally found are benign lesions. Focal nodular hyperplasia (FNH) is the second most common benign solid hepatic mass that does not transform to malignancy. A 43-year-old woman who was diagnosed with breast cancer recently visited our clinic for evaluation of an incidentally found hepatic mass. Abdominal computed tomography and magnetic resonance imaging showed two lesions on segment 6 of the liver, suggestive of FNH. The patient had undergone surgery for breast cancer and had been taking tamoxifen. We followed the lesions on abdominal ultrasound every six months. Imaging at two years after diagnosis revealed fatty change of the liver parenchyma and increased size and number of masses. Liver biopsy was performed to distinguish metastatic lesions. Conclusively, FNH with drug-induced steato-hepatitis was confirmed by histopathologic finding. We are following the patient with imaging study and liver fibroscan.