Abstract
To the Editor: Dupilumab is a fully human monoclonal antibody that binds the interleukin (IL) 4 receptor-α subunit and inhibits signaling of IL-4 and IL-13. It was approved by the Food and Drug Administration for the treatment of moderate to severe atopic dermatitis in adults and adolescents, with efficacy in reducing pruritus.1 The 2 most common subtypes of cutaneous T-cell lymphoma are mycosis fungoides and Sézary syndrome. Mycosis fungoides, Sézary syndrome and atopic dermatitis are similarly driven by T-helper 2 cytokine profiles2 and may present with similar morphology (ie, erythema, lichenification, fissuring) with pruritus,3 disruption of the skin barrier, and impetiginization.
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