Progressing towards personalised medicine: the Genomic Data Infrastructure (GDI) project

Abstract

Abstract Funded by the European Commission under the Digital Europe Programme and through co-funding from participating Member States, the European Genomic Data Infrastructure (GDI) aims to support the 1+Million Genome initiative for establishing an effective data infrastructure for genomic data. GDI has the potential to fill the gap between genomic research and clinical practice, promoting the implementation of data-driven precision medicine in Europe with the harmonisation of genomic and related phenotypic and clinical data across adhering countries. Launched in November 2022, the GDI project is a collaborative effort involving partners from 20 European countries, divided into 8 Work Packages across three Pillars. GDI is structured with the development of a framework (Pillar I Long-term sustainability) and the necessary tools (Pillar II 1+MG infrastructure deployment), with the implementations of use cases (Pillar III Application and innovation solution) to support research and innovation, integrate findings into the clinic and healthcare, and improve public health measures. In the first 2 years, we completed the starter kit which we are currently testing with real data. Over the subsequent years, the GDI project aims to provide a federated and sustainable infrastructure for facilitating research that use genomic data. Through authorized secure access, clinicians and researchers can leverage genomic insights for faster and more precise clinical decision-making, diagnosis, and treatments. The GDI project represents a significant opportunity to improve healthcare outcomes and public health measures by leveraging the potential of genomics. By providing secure access to extensive genomic datasets combined with phenotyped data, the infrastructure sets the foundation for international partnerships in personalized medicine. Ultimately, this initiative holds the promise of advancing medical understanding, enhancing patient care, and fostering economic growth across Europe. Key messages • GDI drives personalised medicine via international collaboration, building a sustainable infrastructure. Harmonizing data accelerates innovation, improving outcomes and fostering growth in Europe. • GDI aims to revolutionize healthcare by collecting and harmonizing genomic and clinical data in Europe. It facilitates faster and more precise decisions and treatments, improving healthcare outcomes.