Abstract
Classification criteria are needed to aid recruitment of appropriate patients into research studies. The International Myositis Classification Criteria Project (IMCCP) was set up with support from ACR and EULAR.
Highlights
Classification criteria are needed to aid recruitment of appropriate patients into research studies
Candidate criteria variables were taken from published criteria and inclusion criteria from clinical trials of myositis
Clinical and laboratory data from IIM and comparator patients were collected from 47 rheumatology, dermatology, neurology and pediatrics clinics worldwide from 2008-2011
Summary
To develop and validate new classification criteria for adult and juvenile IIM. Pair-wise associations among all items and between each item and clinicians’ diagnoses were assessed. Three approaches for derivation of classification criteria were explored: Traditional, Probability score and Classification tree. Internal validation using bootstrap methods and external validation using data from the Euromyositis register and the Juvenile Dermatomyositis cohort biomarker study and repository UK and Ireland was performed
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